Effect of Occupational Noise Exposure on Sleep among Workers of Textile Industry
Published: March 1, 2018 | DOI: https://doi.org/10.7860/JCDR/2018/26084.11334
Zahra Darzi Azadboni, Roghaeh Jafari Talarposhti, Maryam Ghaljahi, Ahmad Mehri, Saeid Aarabi, Mohsen Poursadeghiyan, Milad Abbasi
1. Postgraduate Student, Student Research Committee, Faculty of Health and Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
2. Postgraduate Student, Student Research Committee, Faculty of Health and Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
3. Instructor, Department of Occupational Health Engineering, School of Public Health, Zabol University of Medical Sciences, Zabol, Iran.
4. Department of Occupational Health Engineering, School of Public Health, Iranshahr University of Medical Sciences, Iranshahr, Iran.
5. PhD Student, Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
6. Assistant Professor, Research Center in Emergency and Disaster Health, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Correspondence
Mr. Milad Abbasi,
Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences,
Kermanshah, Iran; PhD Student, Department of Occupational Health Engineering, Students’ Scientific Research Center,
Tehran University of Medical Sciences, Tehran, Iran.
E-mail: milad8285@gmail.com
Introduction: Insulin-like Growth Factor (IGF) signaling pathway has important roles in regulating cellular proliferation, apoptosis, differentiation and transformation. IGF-axis is implicated in pathogenesis of several common cancers including cancer cervix and its pre cancer stage.
Aim: To measure the circulating levels of IGF-I, IGF-II and IGFBP-3 and evaluate their association with early stages of cancer cervix.
Materials and Methods: The present case-control study consisted of 29 histologically proven cases of early cancer cervix (FIGO Stage I and II) and 37 age matched cytologically proven normal healthy controls. The study was conducted in Department of Biochemistry, Maulana Azad Medical College, Delhi, India from May 2004-April 2007. Peripheral blood was drawn in a heparinized vial and plasma was separated by centrifugation and stored at -80°C till analysis. Concentration of IGF-I, IGF-II and IGFBP-3 was measured using commercially available ELISA kit (DRG Diagnostics) in units of ng/mL. Statistical analysis was done using SPSS statistics (V21.0) and Microsoft excel software, viz. Student-t-test for comparison of significant mean, binary logistic regression was used to measure Odds Ratios (OR). Bio-Effective Mitogen (BEM) was calculated as (IGF-I in nM+IGF-II in nM+100)–(90% IGFBP-3 in nM) and mitogenic index as BEM/10% IGFBP-3 in nM.
Results: Plasma levels of IGF-I were significantly decreased (p<0.01) while IGF-II levels were not significantly different between cases and controls (p=0.12). IGFBP-3 levels were decreased significantly in cases than controls (p<0.01). Mitogenic index was significantly increased in cases as compared to controls (p=0.01). OR for cancer cervix was calculated based on distribution of 50th percentile in control group and OR (95% CI) was 3.5 (1.04-11.73); p=0.04.
Conclusion: Circulating IGF-I, IGF-II and IGFBP-3 are in a dynamic relationship; hence, mitogenic index was educed from these factors. We found mitogenic index to be associated with cancer cervix in concordance to the cognizant role of IGFs and their binding proteins.
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